Poppelsdorfer Schlossgespräche

Prof. Dr. Michael Dustin
2021-01-20 19:15 (Europe/Paris) | Online via Zoom
“T cells on the attack against cancer and infection“
In this lecture, Prof. Dustin will introduce the “immunological synapse”, the specialized junction between immune cells and their targets. Thereby, he will discuss three recent examples concerning
1. molecular dynamics in the context of cancer immunotherapy;
2. the inhibition of the immunological synapse by plasmodium;
3. “protein bombs” from T-cells killing cancerous and infected cells.
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Prof. Dr. Dr. Haass
2020-12-03 19:15
“Can we ever treat Alzheimer’s disease?“
In his lecture, the Professor will explain the pathology of Alzheimer’s disease and the hypothesis of the amyloid cascade. With this basis, he will further describe amyloid-based therapeutic approaches, their clinical issues and finally he will address neuroinflammation as a new therapeutic target.

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Prof. Dr. Hannes Mutschler
2020-11-17 19:15
Full Professor for Biomimetic Chemistry, TU Dortmund, since November 2020
“Bottom-up approaches in origins of life research and synthetic biology”
The bottom-up generation of chemical systems with life-like properties is a key objective of synthetic biology and origin of life research. In his talk, Prof. Dr. Mutschler will present his research, which focuses on the assembly of self-replicating systems from existing biological parts. Furthermore, he will discuss the potential role of nucleic acid catalysts, such as ribozymes, as key players in an early biology that preceded modern life on Earth.

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Dr. Martin Denzel
2020-11-05 19:15
Leader of the workgroup for Metabolic and Genetic Regulation of Ageing, MPI for Biology of Ageing in Cologne
“Mutagenesis screens define unexpected roles of metabolism and protein synthesis in longevity”
Understanding the metabolic and genetic regulation of ageing requires multiple parallel approaches. In his lecture, Dr. Denzel presents his lab’s investigations of the metabolic modulation of protein homeostasis, mechanisms that control protein synthesis, and the role of stress resistance in longevity.

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