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X-WR-CALNAME:Poppelsdorfer Schlossgespräche
X-ORIGINAL-URL:http://schlossgespraeche.org
X-WR-CALDESC:Events for Poppelsdorfer Schlossgespräche
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TZID:Europe/Paris
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DTSTART;TZID=Europe/Paris:20211012T190000
DTEND;TZID=Europe/Paris:20211012T200000
DTSTAMP:20260407T172600
CREATED:20211011T123251Z
LAST-MODIFIED:20211011T125112Z
UID:787-1634065200-1634068800@schlossgespraeche.org
SUMMARY:Prof. Brian Kobilka M.D
DESCRIPTION:“G-Protein-Coupled-Receptors” \nIn this lecture\, the Nobel prize winner Prof. Kobilka gives us an insight into the family of G -Protein-Coupled-Receptors (GPCR)\, the largest family of cell surface receptors. Given the role in regulation of all aspects of human physiology GPCR are the main target of today’s pharmaceuticals. He will discuss approaches to characterize the structure and mechanistic activation of GPCR at molecular level. \nResearch in the Kobilka Lab is focused on G protein coupled receptors (GPCRs)\, a large family of membrane bound receptors that mediate the majority of physiologic responses to hormones and neurotransmitters\, as well as the senses of sight\, smell and taste. They apply a range of structural and biophysical methods to study the mechanism of  transmembrane signaling by GPCRs. High resolution structures obtained by crystallography and cryo-electron microscopy have captured several GPCRs in inactive and active states\, while fluorescence\, EPR and NMR spectroscopy reveal the dynamic behavior of receptors as they transition between these states. The lab is interested in developing structure-based approaches to facilitate drug discovery.
URL:http://schlossgespraeche.org/event/prof-brian-kobilka-m-d/
LOCATION:Online via Zoom
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20210120T191500
DTEND;TZID=Europe/Paris:20210120T191500
DTSTAMP:20260407T172600
CREATED:20201124T121343Z
LAST-MODIFIED:20210112T165508Z
UID:675-1611170100-1611170100@schlossgespraeche.org
SUMMARY:Prof. Dr. Michael Dustin
DESCRIPTION:“T cells on the attack against cancer and infection“ \nIn this lecture\, Prof. Dustin will introduce the “immunological synapse”\, the specialized junction between immune cells and their targets. Thereby\, he will discuss three recent examples concerning\n1. molecular dynamics in the context of cancer immunotherapy;\n2. the inhibition of the immunological synapse by plasmodium;\n3. “protein bombs” from T-cells killing cancerous and infected cells. \nDownload Flyer here
URL:http://schlossgespraeche.org/event/prof-dr-michael-dustin/
LOCATION:Online via Zoom
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20201203T191500
DTEND;TZID=Europe/Paris:20201203T191500
DTSTAMP:20260407T172600
CREATED:20191126T172735Z
LAST-MODIFIED:20201028T171437Z
UID:89-1607022900-1607022900@schlossgespraeche.org
SUMMARY:Prof. Dr. Dr. Haass
DESCRIPTION:“Can we ever treat Alzheimer’s disease?“ \nIn his lecture\, the Professor will explain the pathology of Alzheimer’s disease and the hypothesis of the amyloid cascade. With this basis\, he will further describe amyloid-based therapeutic approaches\, their clinical issues and finally he will address neuroinflammation as a new therapeutic target. \n  \nDownload Flyer here
URL:http://schlossgespraeche.org/event/haass/
LOCATION:Online via Zoom
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20201117T191500
DTEND;TZID=Europe/Paris:20201117T191500
DTSTAMP:20260407T172600
CREATED:20201020T170326Z
LAST-MODIFIED:20201028T171545Z
UID:380-1605640500-1605640500@schlossgespraeche.org
SUMMARY:Prof. Dr. Hannes Mutschler
DESCRIPTION:Full Professor for Biomimetic Chemistry\, TU Dortmund\, since November 2020 \n“Bottom-up approaches in origins of life research and synthetic biology” \nThe bottom-up generation of chemical systems with life-like properties is a key objective of synthetic biology and origin of life research. In his talk\, Prof. Dr. Mutschler will present his research\, which focuses on the assembly of self-replicating systems from existing biological parts. Furthermore\, he will discuss the potential role of nucleic acid catalysts\, such as ribozymes\, as key players in an early biology that preceded modern life on Earth. \n  \nDownload Flyer here
URL:http://schlossgespraeche.org/event/mutschler/
LOCATION:Online via Zoom
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20201105T191500
DTEND;TZID=Europe/Paris:20201105T191500
DTSTAMP:20260407T172600
CREATED:20200407T111343Z
LAST-MODIFIED:20201028T171444Z
UID:173-1604603700-1604603700@schlossgespraeche.org
SUMMARY:Dr. Martin Denzel
DESCRIPTION:Leader of the workgroup for Metabolic and Genetic Regulation of Ageing\, MPI for Biology of Ageing in Cologne \n“Mutagenesis screens define unexpected roles of metabolism and protein synthesis in longevity” \nUnderstanding the metabolic and genetic regulation of ageing requires multiple parallel approaches. In his lecture\, Dr. Denzel presents his lab’s investigations of the metabolic modulation of protein homeostasis\, mechanisms that control protein synthesis\, and the role of stress resistance in longevity. \n  \nDownload Flyer here
URL:http://schlossgespraeche.org/event/denzel/
LOCATION:Online via Zoom
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